Woodworth, Kate R;
Moulia, Danielle;
Collins, Jennifer P;
Hadler, Stephen C;
Jones, Jefferson M;
Reddy, Sujan C;
Chamberland, Mary;
Campos-Outcalt, Doug;
Morgan, Rebecca L;
Brooks, Oliver;
Talbot, H. Keipp;
Lee, Grace M;
Bell, Beth P;
Daley, Matthew F;
Mbaeyi, Sarah;
Dooling, Kathleen;
Oliver, Sara E.
The Pfizer-BioNTech COVID-19 (BNT162b2) vaccine is a lipid nanoparticle–formulated, nucleoside-modified mRNA vaccine encoding the prefusion spike glycoprotein of SARS-CoV-2, the virus that causes COVID-19. On August 23, 2021, the Food and Drug Administration (FDA) approved a Biologics License Applicati...
Fleming-Dutra, Katherine E;
Wallace, Megan;
Moulia, Danielle L;
Twentyman, Evelyn;
Roper, Lauren E;
Hall, Elisha;
Link-Gelles, Ruth;
Godfrey, Monica;
Woodworth, Kate R;
Anderson, Tara C;
Rubis, Amy B;
Shanley, Edwin;
Jones, Jefferson M;
Morgan, Rebecca L;
Brooks, H. Oliver;
Talbot, Keipp;
Lee, Grace M;
Bell, Beth P;
Meyer, Sarah;
Daley, Matthew;
Oliver, Sara E.
On June 17, 2022, the Food and Drug Administration (FDA) issued Emergency Use Authorization (EUA) amendments for the mRNA-1273 (Moderna) COVID-19 vaccine for use in children aged 6 months–5 years, administered as 2 doses (25 µg [0.25 mL] each), 4 weeks apart, and BNT162b2 (Pfizer-BioNTech) COVID-19 va...
Wallace, Megan;
Moulia, Danielle;
Blain, Amy E;
Ricketts, Erin K;
Minhaj, Faisal S;
Link-Gelles, Ruth;
Curran, Kathryn G;
Hadler, Stephen C;
!Asif, Amimah;
Godfrey, Monica;
Hall, Elisha;
Fiore, Anthony;
Meyer, Sarah;
Su, John R;
Weintraub, Eric;
Oster, Matthew E;
Shimabukuro, Tom T;
Campos-Outcalt, Doug;
Morgan, Rebecca L;
Bell, Beth P;
Brooks, Oliver;
Talbot, H. Keipp;
Lee, Grace M;
Daley, Matthew F;
Oliver, Sara E.
The mRNA-1273 (Moderna) COVID-19 vaccine is a lipid nanoparticle-encapsulated, nucleoside-modified mRNA vaccine encoding the stabilized prefusion spike glycoprotein of SARS-CoV-2, the virus that causes COVID-19. During December 2020, the vaccine was granted Emergency Use Authorization (EUA) by the Food a...
Oliver, Sara E;
Wallace, Megan;
See, Isaac;
Mbaeyi, Sarah;
Godfrey, Monica;
Hadler, Stephen C;
Jatlaoui, Tara C;
Twentyman, Evelyn;
Hughes, Michelle M;
Rao, Agam K;
Fiore, Anthony;
Su, John R;
Broder, Karen R;
Shimabukuro, Tom;
Lale, Allison;
Shay, David K;
Markowitz, Lauri E;
Wharton, Melinda;
Bell, Beth P;
Brooks, Oliver;
McNally, Veronica;
Lee, Grace M;
Talbot, H. Keipp;
Daley, Matthew F.
On February 27, 2021, the Food and Drug Administration (FDA) issued an Emergency Use Authorization (EUA) for the adenovirus-vectored COVID-19 vaccine (Janssen Biotech, Inc., a Janssen Pharmaceutical company, Johnson & Johnson), and on February 28, 2021, the Advisory Committee on Immunization Practices (A...
Wu, Lei;
Chen, Yaolong;
Ma, Yanfang;
Yang, Zifeng;
Yang, Nan;
Denga, Wenze;
Chen, Yuanbin;
Sun, Yuanyuan;
Li, Yimin;
Lin, Lin.
Influenza is a major public health problem worldwide. Mutations and resistance development make the use of antiviral therapy challenging. Chinese patent medicines are often used to treat influenza in China and well tolerable. However, the misuse of Chinese patent medicines is common. We therefore aimed t...
Jin, Ying-Hui;
Zhan, Qing-Yuan;
Peng, Zhi-Yong;
Ren, Xue-Qun;
Yin, Xun-Tao;
Cai, Lin;
Yuan, Yu-Feng;
Yue, Ji-Rong;
Zhang, Xiao-Chun;
Yang, Qi-Wen;
Ji, Jianguang;
Xia, Jian;
Li, Yi-Rong;
Zhou, Fu-Xiang;
Gao, Ya-Dong;
Yu, Zhui;
Xu, Feng;
Tu, Ming-Li;
Tan, Li-Ming;
Yang, Min;
Chen, Fang;
Zhang, Xiao-Ju;
Zeng, Mei;
Zhu, Yu;
Liu, Xin-Can;
Yang, Jian;
Zhao, Dong-Chi;
Ding, Yu-Feng;
Hou, Ning;
Wang, Fu-Bing;
Chen, Hao;
Zhang, Yong-Gang;
Li, Wei;
Chen, Wen;
Shi, Yue-Xian;
Yang, Xiu-Zhi;
Wang, Xue-Jun;
Zhong, Yan-Jun;
Zhao, Ming-Juan;
Li, Bing-Hui;
Ma, Lin-Lu;
Zi, Hao;
Wang, Na;
Wang, Yun-Yun;
Yu, Shao-Fu;
Li, Lu-Yao;
Huang, Qiao;
Weng, Hong;
Ren, Xiang-Ying;
Luo, Li-Sha;
Fan, Man-Ru;
Huang, Di;
Xue, Hong-Yang;
Yu, Lin-Xin;
Gao, Jin-Ping;
Deng, Tong;
Zeng, Xian-Tao;
Li, Hong-Jun;
Cheng, Zhen-Shun;
Yao, Xiaomei;
Wang, Xing-Huan.
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness,
coronavirus disease 2019 (COVID-19), affecting more than seventeen million people around the world. Diagnosis
and treatment guidelines for clinicians caring for patients are needed. In the ...
Quimioprevención/métodos,
Infecciones por Coronavirus/diagnóstico,
Infecciones por Coronavirus/tratamiento farmacológico,
Neumonía Viral/diagnóstico,
Neumonía Viral/tratamiento farmacológico,
Pandemias/prevención & control,
Betacoronavirus/efectos de los fármacos,
Práctica Clínica Basada en la Evidencia/métodos,
Antirretrovirales/uso terapéutico,
Lopinavir/uso terapéutico,
Cloroquina/uso terapéutico,
Receptores de Interleucina-6/uso terapéutico,
Hidroxicloroquina/uso terapéutico,
Plasma/inmunología
Rochwerg, Bram;
Agarwal, Arnav;
Zeng, Linan;
Leo, Yee-Sin;
Appiah, John Adabie;
Agoritsas, Thomas;
Bartoszko, Jessica;
Brignardello-Petersen, Romina;
Ergan, Begum;
Ge, Long;
Geduld, Heike;
Gershengorn, Hayley B;
Manai, Hela;
Huang, Minhua;
Lamontagne, François;
Kanda, Seema;
Kawano-Dourado, Leticia;
Kurian, Linda;
Kwizera, Arthur;
Murthy, Srinivas;
Qadir, Nida;
Siemieniuk, Reed;
Silvestre, Maria Asuncion;
Vandvik, Per Olav;
Ye, Zhikang;
Zeraatkar, Dena;
Guyatt, Gordon.
Clinical question: What is the role of remdesivir in the treatment of severe covid-19? This guideline was triggered by the ACTT-1 trial published in the New England Journal of Medicine on 22 May 2020.Remdesivir has received worldwide attention as a potentially effective treatment for severe covid-19. Aft...
Chawla, Deepak;
Chirla, Dinesh;
Dalwai, Samir;
deorari, Ashok K;
Ganatra, Atul;
Gandhi, Alpesh;
Kabra, Nandkishor S;
Kumar, Praveen;
Mittal, Pratima;
Parekh, Bakul Jayant;
Sankar, M Jeeva;
Singhal, Tanu;
Sivanandan, Sindhu;
Tank, Parikshit.
During the current rapidly evolving pandemic of COVID-19 infection, pregnant women with suspected or confirmed COVID-19 and their newborn infants form a special vulnerable group that needs immediate attention. Unlike other elective medical and surgical problems for which care can be deferred during the p...
Falavigna, Maicon;
Colpani, Verônica;
Stein, Cinara;
Azevedo, Luciano César Pontes;
Bagattini, Ângela Maria;
Brito, Gabriela Vilela de;
Chatkin, José Miguel;
Cimerman, Sérgio;
Corradi, Mirian de Freitas Dal Ben;
Cunha, Clóvis Arns da;
Medeiros, Flávia Cordeiro de;
Oliveira Júnior, Haliton Alves de;
Fritscher , Leandro Genehr;
Gazzana, Marcelo Basso;
Graf, Débora Dalmas;
Marra, Lays Pires;
Matuoka , Jéssica Yumi;
Nunes, Michelle Silva;
Pachito, Daniela Vianna;
Pagano, Cássia Garcia Moraes;
Parreira, Patrícia do Carmo Silva;
Riera, Rachel;
Silva Júnior, Amilton;
Tavares, Bruno de Melo;
Zavascki, Alexandre Prehn;
Rosa, Régis Goulart;
Dal-Pizzol, Felipe.
Different therapies are currently used, considered, or proposed for the treatment of COVID-19; for many of those therapies, no appropriate assessment of effectiveness and safety was performed. This document aims to provide scientifically available evidence-based information in a transparent interpretatio...
Infecciones por Coronavirus/tratamiento farmacológico,
Aminoquinolinas/uso terapéutico,
Oseltamivir/uso terapéutico,
Lopinavir/uso terapéutico,
Ritonavir/uso terapéutico,
Corticoesteroides/uso terapéutico,
Heparina/uso terapéutico,
Antibacterianos/uso terapéutico,
Betacoronavirus/efectos de los fármacos,
Neumonía Viral/tratamiento farmacológico,
Pandemias/prevención & control
Lindner, Andreas K;
Lejon, Veerle;
Chappuis, François;
Seixas, Jorge;
Kazumba, Leon;
Barrett, Michael P;
Mwamba, Erick;
Erphas, Olema;
Akl, Elie A;
Villanueva, Gemma;
Bergman, Hanna;
Simarro, Pere;
Ebeja, Augustin Kadima;
Priotto, Gerardo;
Franco, Jose Ramon.
Human African trypanosomiasis caused by Trypanosoma brucei gambiense is a parasitic infection that usually progresses to coma and death unless treated. WHO has updated its guidelines for the treatment of this infection on the basis of independent literature reviews and using the Grading of Recommendation...
